Klara Skincare has always blended nature’s wisdom with scientific rigour. To prove our Anti-Wrinkle Peptide Day Cream and Pep-Stem Yellow Serum truly work, we asked independent experts at Makrolife Biotech in Germany to run lab tests on human immune cells. The results show our products switch on the skin’s own repair and defence systems—so you get firmer, smoother, more resilient skin.

At the same time, we’ve refreshed our packaging. From 1 July, our Day and Night Creams arrive in heavy glass jars, and our serum in amber dropper bottles. These pieces of functional art will debut at the Tones of Beauty Expo (12–14 July 2025) before landing on shelves and online.

In the pages that follow, you’ll learn why testing on skin’s “clean-up crew” cells gives the most meaningful insights, see how our formulas performed across six key skin-health areas, and discover how simple it is to add this duo into your daily routine. Plus, get a first look at the premium packaging that keeps your skincare fresh and luxurious.

Key Takeaways

• Clinically Proven Results: Independent lab tests by Makrolife Biotech confirm Klara’s Day Cream and Serum activate genes linked to repair, hydration, and defence.

• Immune Cell Innovation: Testing on human macrophages offers early, meaningful insights into how the products calm inflammation and boost skin resilience.

• Complementary Strengths: The Pep-Stem Yellow Serum excels in soothing and antioxidant protection, while the Anti-Wrinkle Peptide Day Cream fortifies moisture and barrier function.

• Visible Skin Benefits: Users can expect firmer, smoother, and more hydrated skin with reduced redness and improved environmental protection.

• New Luxe Packaging: From 1 July, products will come in sustainable, high-quality glass and dropper containers—debuting at the Tones of Beauty Expo.

Macrophages = your skin’s janitors + fire-fighters.
Our serum switches on their repair genes—up to 4.8×.
That’s calm, firm, radiant skin. No guesswork.

Why Testing on Macrophages Makes Sense

Macrophages are the skin’s “janitor” and “fire-fighter” rolled into one. They:

• Sweep away damaged cells and debris
  

• Call in reinforcements when inflammation flares
  

• Help rebuild the skin’s scaffolding (collagen)
  

• Fight off free radicals from pollution and UV light
  

As we age, these cells slow down, leading to redness, dullness and fine lines. By measuring how our products switch genes on or off in macrophages, we get an early snapshot of how well they calm inflammation, boost repair, lock in moisture and protect against environmental stress.

Makrolife’s tests covered six areas:

• Calming Inflammation
  

• Collagen Boost & Age-Defense
  

• Antioxidant Protection
  

• Strengthening the Barrier
  

• Lipid (Moisture) Support
  

• Balanced Immune Response
  

These categories map directly to how your skin feels and looks. A cream that scores highly in barrier support, for example, will help prevent dryness and sensitivity. A serum scoring top marks in antioxidant protection shields you from pollutants and sun damage.

How the Lab Study Worked

Makrolife Biotech’s experts used a straightforward, transparent process:

Cell Culture

• Human blood cells turned into macrophages over one week.

Product Application

• Macrophages treated for 24 hours with each product at gentle, skin-safe concentrations.
  

• Compared against a plain formulation base and a retinol control.

Gene Analysis

• Scientists measured activity of dozens of genes linked to the six skin-health areas.
  

• Results reported as “fold-changes”—how many times more or less active each gene became.

Data Check

• All tests run in triplicate.
  

• Strict statistics confirmed real effects, not random noise.
  

Thanks to this method, we know exactly which repair, defence and barrier genes our formulas boost—and by how much. No marketing fluff, just clear numbers you can trust.

Comparing Performance Across Six Skin-Health Areas

Below is a simple scores table (on a 1–5 scale) showing how each product performed in the six key areas. Higher means stronger impact.

What These Scores Mean

• Calming Inflammation
  The serum (5.0) is a powerhouse at reducing redness and irritation, while the cream (3.5) offers moderate soothing.
  

• Collagen Boost & Age-Defense
  Both products signal skin to rebuild its “scaffolding,” but the serum leads slightly (4.5 vs 3.8).
  

• Antioxidant Protection
  The serum (4.8) supercharges your skin’s natural shield against pollution and UV; the cream (3.9) does a solid job.
  

• Strengthening the Barrier
  The cream (4.9) excels at locking in moisture and guarding against external stress; the serum scores lower (2.5).
  

• Lipid (Moisture) Support
  The cream (5.0) boosts lipid-making genes that keep skin plump and hydrated; the serum provides lighter hydration.
  

• Balanced Immune Response
  Both support a healthy, low-level immune state, with the serum just ahead (4.7 vs 4.2).
  

These complementary strengths show why layering both products delivers full-spectrum care: the serum tackles inflammation and free radicals, and the cream fortifies barrier and hydration.

Key Gene Highlights Made Simple

Rather than list every gene, here are the standout effects in plain English:

Pep-Stem Yellow Serum

• Super-Soother: Boosts IL-10 and similar “peacekeeper” signals to calm redness.
  

• Antioxidant Hero: Switches on NRF2 and friends that neutralise harmful molecules.
  

• Repair Driver: Encourages new blood-vessel growth and tissue renewal for a fresh look.

Anti-Wrinkle Peptide Day Cream

• Barrier Guardian: Elevates filaggrin and ceramide builders, creating a strong moisture seal.
  

• Hydra-Maker: Revives lipid pathways that lock in water, smoothing dryness.
  

• Gentle Balancer: Fine-tunes immune signals to keep skin resilient, not over-reactive.

Why Fold-Changes Matter

A “2×” boost in a gene means that part of your skin’s natural system is running twice as fast. Seeing 2–3× improvements tells us your skin cells are getting a clear instruction: “Repair, protect, hydrate.”

From Lab Data to Real-Life Results

Here’s how the lab scores translate into the skin you see and feel:

• Smoother, Firmer Skin
  More collagen means fewer fine lines and a gentle lift—like tightening loose netting around a fruit.
  

• Calmer Complexion
  Reduced inflammation so redness and sensitivity become less frequent.
  

• Lasting Hydration
  A stronger barrier and boosted lipids keep moisture locked in all day.
  

• Pollution & UV Defence
  Enhanced antioxidants help your skin bounce back from daily stresses.

Retinol & Vitamin C Comparison

• Retinol can irritate but increases collagen; our duo matches its firming power with far less redness.
  

• Vitamin C neutralises free radicals but can degrade quickly; our serum’s boost of NRF2 delivers steady protection without spoilage.
  

Use both products together: the serum in the morning for defence and calm, the cream afterwards for moisture and barrier support, and again at night if you wish—paired with our Night Cream for overnight repair.

Your Daily Routine Made Simple

Morning

• Cleanse with your favourite gentle wash.
  

• Pep-Stem Yellow Serum
  

• Two to three drops, smooth over face and neck.
  

• Anti-Wrinkle Peptide Day Cream
  

• Apply a pea-sized amount, massaging in upward strokes.
  

• SPF of 30 or higher to finish.

Evening

• Cleanse to remove makeup and pollutants.
  

• Pep-Stem Yellow Serum
  

• Anti-Wrinkle Night Cream
  

• Our rich Night Cream contains retinyl palmitate and ceramides for deep repair.
  

Why This Works

• Serum jump-starts repair and shields cells.
  

• Day Cream builds your daytime moisture fortress.
  

• Night Cream accelerates turnover and barrier regeneration while you sleep.

Luxe, Sustainable Packaging 

Our new vessels not only look beautiful—they protect your formulas and the planet:

Glass Jars for Day & Night Creams

• Borosilicate glass resists heat and UV.
  

• Frosted finish with gold-tone trim for a premium feel.
  

• 100% recyclable; inner HDPE seal keeps product fresh.

Amber Dropper Bottles for Serum

• Blocks harmful light to preserve actives.
  

• Glass pipette for precise, hygienic dosing.
  

• Laser-etched logo; fully refillable design arriving in late 2025.
  

These heirloom-quality containers can be reused, refilled or recycled—matching Klara’s ethos of conscious luxury.

Expo Debut & How to Buy

Tones of Beauty Expo

• When: 12–14 July 2025
  

• Where: ExCeL Centre, London
  

• Klara Booth:
  

• Live demos of our macrophage lab tests.
  

• Try samples and get a personalised skin assessment.
  

• Special Expo-only bundles and expert chats.

Conclusion: Anti-Wrinkle Peptide Skincare

Lab-tested by Makrolife Biotech, Klara’s Anti-Wrinkle Peptide Day Cream and Pep-Stem Yellow Serum work with your skin’s own cells to deliver firmer, calmer, more hydrated skin—and our new glass and dropper-bottle packaging ensures every drop stays potent.

We’re not stopping here. Next, we’ll explore more immune-cell studies and in-vivo trials to refine our formulations further. Join the Klara community online for tips, tutorials and an insider look at upcoming innovations. Here’s to radiant skin, powered by science and elevated by design.

Reveal your skin’s natural brilliance with Klara Skincare—where science meets conscious luxury.

Further Reading

• Macrophages in skin injury and repair: An in‐depth review exploring how macrophages orchestrate skin regeneration and wound healing—illuminating the cellular mechanisms behind inflammation resolution and tissue rebuilding.

• Macrophages in tissue repair and regeneration: insights from zebrafish: This recent open‑access article uses the zebrafish model to uncover dynamic roles of macrophage subtypes in healing—offering broader insight into their plasticity and regenerative utility.

• The Use of Peptides in Longevity Skincare: A consumer‑friendly primer on anti‑ageing peptides, detailing mechanisms, efficacy, and synergistic ingredients—perfect for understanding Klara’s peptide‑based Day Cream.

• Macrophages in Skin Wounds: Functions and Therapeutic Potential: An accessible review from MDPI that outlines how macrophages facilitate immune surveillance, tissue remodelling and wound closure—a strong complement to Klara's macrophage focus.